Title : Aβ monomer induces phosphorylation of Tau at Ser-214 through β2AR-PKA-JNK signaling pathway.

Pub. Date : 2020 Apr

PMID : 32067279






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In our study, we found that Abeta-M expression slowly induced cell apoptosis within 48 hours after transfection, beta2 adrenergic receptor (beta2AR) interacted with Abeta-M in the pull-down and the yeast two-hybrid assays, and Abeta-M played a major role in inducing phosphorylation of Tau at Ser-214, c-Jun N-terminal kinase (JNK) at Thr-183/Tyr-185, p70 ribosomal protein S6 kinase (p70S6K) at Thr-389. Threonine adrenoceptor beta 2 Homo sapiens