Title : MY-5445, a phosphodiesterase type 5 inhibitor, resensitizes ABCG2-overexpressing multidrug-resistant cancer cells to cytotoxic anticancer drugs.

Pub. Date : 2020

PMID : 32064159






1 Functional Relationships(s)
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1 The overexpression of one or multiple ATP-binding cassette (ABC) transporters such as ABCB1, ABCC1 or ABCG2 in cancer cells often leads to the development of multidrug resistance phenotype and consequent treatment failure. Adenosine Triphosphate ATP binding cassette subfamily B member 1 Homo sapiens