Pub. Date : 2019
PMID : 32063716
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of ISG15 Enhances the Anti-Cancer Effect of Trametinib in Colon Cancer Cells. | trametinib | ISG15 ubiquitin like modifier | Homo sapiens |
| 2 | ISG15 expression levels of colon cancer cells treated with trametinib was verified by using the data downloaded from the Gene Expression Omnibus (GEO) databases, quantitative real-time PCR analysis and Western blots assays. | trametinib | ISG15 ubiquitin like modifier | Homo sapiens |
| 3 | In addition, we first found that the mRNA and protein expression of ISG15 were up-regulated following trametinib treatment. | trametinib | ISG15 ubiquitin like modifier | Homo sapiens |
| 4 | Further investigation showed that ISG15 knockdown could enhance the anti-cancer effect of trametinib in colon cancer cells. | trametinib | ISG15 ubiquitin like modifier | Homo sapiens |