Pub. Date : 2020
PMID : 32047580
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chondroprotective Effect of Cynaroside in IL-1beta-Induced Primary Rat Chondrocytes and Organ Explants via NF-kappaB and MAPK Signaling Inhibition. | luteolin-7-glucoside | interleukin 1 alpha | Rattus norvegicus |
| 2 | In this study, we investigated the chondroprotective effects of cynaroside on IL-1beta-stimulated chondrocytes and organ explants. | luteolin-7-glucoside | interleukin 1 alpha | Rattus norvegicus |
| 3 | Cynaroside inhibited IL-1beta-induced expression of catabolic factors (nitrite, iNOS, ROS, PGE2, Cox-2, MMP-1, MMP-3, MMP-13, and ADAMTS-4) and degradation of anabolic factors (collagen type II and aggrecan). | luteolin-7-glucoside | interleukin 1 alpha | Rattus norvegicus |
| 4 | Furthermore, cynaroside suppressed IL-1beta-induced phosphorylation of MAPKs and translocation of the NF-kappaB p65 subunit into the nucleus. | luteolin-7-glucoside | interleukin 1 alpha | Rattus norvegicus |