Pub. Date : 2020 Jul
PMID : 32036619
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | While best understood for its role in promoting DNA repair, our group has shown that PARP-1 activity can be stimulated via Ca2+ influx-dependent ERK1/2-mediated phosphorylation. | Calcium | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 2 | However, to date, the route of Ca2+ entry responsible for stimulating PARP-1 has not been identified. | Calcium | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 3 | A likely candidate is via Ca2+ -permeable transient receptor potential melastatin 2 (TRPM2) channels activated downstream of PARP-1 in a cascade that involves ADP-ribose (ADPR) production by poly(ADP-ribose) glycohydrolase (PARG). | Calcium | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 4 | Furthermore, we show that Ca2+ influx is necessary to activate PARP-1/TRPM2 signaling, in an ERK1/2-dependent, but DNA damage independent, manner. | Calcium | poly(ADP-ribose) polymerase 1 | Homo sapiens |