Title : The Effects of Dexmedetomidine in a Rat Model of Sepsis-Induced Lung Injury are Mediated Through the Adenosine Monophosphate-Activated Protein Kinase (AMPK)/Silent Information Regulator 1 (SIRT1) Pathway.

Pub. Date : 2020 Feb 8

PMID : 32034118






1 Functional Relationships(s)
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1 RESULTS Dexmedetomidine significantly increased the survival rate and reduced the body temperature of rats in the model group with sepsis-induced lung injury, reduced lung injury, significantly reduced apoptosis in lung tissues, and reduced the expression levels of TNF-alpha, and IL-1ss, and increased the levels of IL-10. Dexmedetomidine tumor necrosis factor Rattus norvegicus