Pub. Date : 2020 May
PMID : 32029440
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | On the other hand, CIC mutant allele (CIC-Y1455F), that escapes c-Src-mediated tyrosine phosphorylation, remains localized to the nucleus and retains strong repressor function against CIC targets, the oncogenic transcription factors ETV1 and ETV5. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |
| 2 | Furthermore, we show that the orally available Src family kinase inhibitor, dasatinib, which prevents EGF-mediated tyrosine phosphorylation of CIC and attenuates elevated ETV1 and ETV5 levels, reduces viability of GBM cells and glioma stem cells (GSC), but not of their control cells with undetectable c-Src activity. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |
| 3 | In fact, GBM cells and GSC expressing the tyrosine-defective CIC mutant (Y1455F) lose sensitivity to dasatinib, further endorsing the effect of dasatinib on Src-mediated tyrosine phosphorylation of CIC. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |
| 4 | In fact, GBM cells and GSC expressing the tyrosine-defective CIC mutant (Y1455F) lose sensitivity to dasatinib, further endorsing the effect of dasatinib on Src-mediated tyrosine phosphorylation of CIC. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |
| 5 | Implications: c-Src tyrosine-phosphorylates CIC exports to cytoplasm and inactivates its repressor function in GBM. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |