Title : Solid-Phase Synthesis of Substrate-Based Dipeptides and Heterocyclic Pseudo-dipeptides as Potential NO Synthase Inhibitors.

Pub. Date : 2020 Mar 18

PMID : 32027778






1 Functional Relationships(s)
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1 Several molecules containing a S-Et- or a S-Me-Itc moiety and mainly belonging to the dipeptide-like and 1,2,4-oxadiazole series were shown to inhibit nNOS and iNOS with IC50 in the 1-50 muM range. Dipeptides nitric oxide synthase 2 Rattus norvegicus