Pub. Date : 2020 Feb 2
PMID : 32024237
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARgamma at Ser273. | seryl-seryl-seryl-arginine | peroxisome proliferator activated receptor gamma | Mus musculus |
| 2 | In obesity, phosphorylation of PPARgamma at Ser273 (pSer273) by cyclin-dependent kinase 5 (CDK5)/extracellular signal-regulated kinase (ERK) orchestrates diabetic gene reprogramming via dysregulation of specific gene expression. | seryl-seryl-seryl-arginine | peroxisome proliferator activated receptor gamma | Mus musculus |
| 3 | In obesity, phosphorylation of PPARgamma at Ser273 (pSer273) by cyclin-dependent kinase 5 (CDK5)/extracellular signal-regulated kinase (ERK) orchestrates diabetic gene reprogramming via dysregulation of specific gene expression. | seryl-seryl-seryl-arginine | peroxisome proliferator activated receptor gamma | Mus musculus |
| 4 | Although many recent studies have focused on the development of non-classical agonist drugs that inhibit the phosphorylation of PPARgamma at Ser273, the molecular mechanism of PPARgamma dephosphorylation at Ser273 is not well characterized. | seryl-seryl-seryl-arginine | peroxisome proliferator activated receptor gamma | Mus musculus |
| 5 | Although many recent studies have focused on the development of non-classical agonist drugs that inhibit the phosphorylation of PPARgamma at Ser273, the molecular mechanism of PPARgamma dephosphorylation at Ser273 is not well characterized. | seryl-seryl-seryl-arginine | peroxisome proliferator activated receptor gamma | Mus musculus |
| 6 | Although many recent studies have focused on the development of non-classical agonist drugs that inhibit the phosphorylation of PPARgamma at Ser273, the molecular mechanism of PPARgamma dephosphorylation at Ser273 is not well characterized. | seryl-seryl-seryl-arginine | peroxisome proliferator activated receptor gamma | Mus musculus |
| 7 | Here, we report that protein phosphatase Mg2+/Mn2+-dependent 1A (PPM1A) is a novel PPARgamma phosphatase that directly dephosphorylates Ser273 and restores diabetic gene expression which is dysregulated by pSer273. | seryl-seryl-seryl-arginine | peroxisome proliferator activated receptor gamma | Mus musculus |
| 8 | Here, we report that protein phosphatase Mg2+/Mn2+-dependent 1A (PPM1A) is a novel PPARgamma phosphatase that directly dephosphorylates Ser273 and restores diabetic gene expression which is dysregulated by pSer273. | seryl-seryl-seryl-arginine | peroxisome proliferator activated receptor gamma | Mus musculus |
| 9 | These findings suggest that PPM1A dephosphorylates PPARgamma at Ser273 and represents a potential target for the treatment of obesity-linked metabolic disorders. | seryl-seryl-seryl-arginine | peroxisome proliferator activated receptor gamma | Mus musculus |