Pub. Date : 2020 Jul
PMID : 32022294
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Influence of SLCO1B1 polymorphisms on lopinavir Ctrough inSerbian HIV/AIDS patients. | Lopinavir | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 2 | Since LPV is a substrate for the SLCO1B1 (OATP1B1)-transporter, the aim of this study was to assess the impact of SLCO1B1 polymorphisms (rs11045819, rs4149032 and rs4149056) on LPV trough plasma concentrations (Ctrough ) in Serbian patients. | Lopinavir | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 3 | Since LPV is a substrate for the SLCO1B1 (OATP1B1)-transporter, the aim of this study was to assess the impact of SLCO1B1 polymorphisms (rs11045819, rs4149032 and rs4149056) on LPV trough plasma concentrations (Ctrough ) in Serbian patients. | Lopinavir | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 4 | Since LPV is a substrate for the SLCO1B1 (OATP1B1)-transporter, the aim of this study was to assess the impact of SLCO1B1 polymorphisms (rs11045819, rs4149032 and rs4149056) on LPV trough plasma concentrations (Ctrough ) in Serbian patients. | Lopinavir | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 5 | In multivariate regression analysis, only the SLCO1B1 rs4149056 polymorphism was independently associated with higher LPV Ctrough [beta=2834.5 (1442-4226.9) ng/mL (p=0.001)]. | Lopinavir | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 6 | CONCLUSIONS: Our results demonstrate a statistically significant influence of the SLCO1B1 rs4149056 polymorphism on higher LPV Ctrough in Caucasian HIV/AIDS- patients. | Lopinavir | solute carrier organic anion transporter family member 1B1 | Homo sapiens |