Title : Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models.

Pub. Date : 2020 Feb 4

PMID : 32019603






2 Functional Relationships(s)
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Protein Name
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1 Silencing of TTBK1 or expression of dominant-negative Rho kinase demonstrates that Abeta induces CRMP2 phosphorylation at threonine 514 in a TTBK1-dependent manner, and TTBK1 enhances Abeta-induced CRMP2 phosphorylation in Rho kinase-dependent manner in vitro. glycyl-threonine amyloid beta (A4) precursor protein Mus musculus
2 Silencing of TTBK1 or expression of dominant-negative Rho kinase demonstrates that Abeta induces CRMP2 phosphorylation at threonine 514 in a TTBK1-dependent manner, and TTBK1 enhances Abeta-induced CRMP2 phosphorylation in Rho kinase-dependent manner in vitro. glycyl-threonine amyloid beta (A4) precursor protein Mus musculus