Pub. Date : 2020 Jan 29
PMID : 32013193
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Germline mutations in cytochrome P450 isoforms 4 and 5 genes (CYP3A4/5) and the ATP-binding cassette B1 gene (ABCB1) may contribute to interindividual tacrolimus PK variability, which may impact clinical outcomes among allogeneic hematopoietic stem cell transplantation (HSCT) patients. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Significant associations were detected between germline variants in CYP3A4/5 and ABCB1 and PK endpoints (e.g., median steady-state tacrolimus concentrations and time to goal tacrolimus concentration). | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Significant associations were detected between germline variants in CYP3A4/5 and ABCB1 and PK endpoints (e.g., median steady-state tacrolimus concentrations and time to goal tacrolimus concentration). | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |