Pub. Date : 2020 May 1
PMID : 32011683
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Genetic influence of ABCG2, UGT1A1 and NR1I2 on dolutegravir plasma pharmacokinetics. | dolutegravir | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 2 | We sought to ascertain the contributory effect of SNPs in four key genes linked to dolutegravir disposition (UGT1A1, ABCG2, CYP3A and NR1I2) on plasma dolutegravir pharmacokinetics. | dolutegravir | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 3 | We sought to ascertain the contributory effect of SNPs in four key genes linked to dolutegravir disposition (UGT1A1, ABCG2, CYP3A and NR1I2) on plasma dolutegravir pharmacokinetics. | dolutegravir | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 4 | CONCLUSIONS: This study showed a pharmacogenetic association between dolutegravir pharmacokinetics and variants in the ABCG2, UGT1A1 and NR1I2 genes, particularly when combined. | dolutegravir | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |