Title : The Anti-Rheumatoid Activity of Niclosamide in Collagen-Induced Arthritis in Rats.

Pub. Date : 2019 Dec

PMID : 32010892






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1 Significantly decreased serum levels of inflammatory biomarkers including TNF-alpha, IL-1beta, and IL-6 were observed in rats treated with high-dose oral NCL or intramuscular injection of diclofenac sodium, compared with groups B and C. Histopathological examination revealed that a high dose of NCL significantly reduced the infiltration of inflammatory cells, synovial hyperplasia, and bone and cartilage destruction. Diclofenac tumor necrosis factor Rattus norvegicus