Title : CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway.

Pub. Date : 2020 May

PMID : 32007561






1 Functional Relationships(s)
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1 Although CYP17A1 exhibited no catalytic activity towards the 5alpha-reduced intermediates, once the C4-C5 double bond and the keto group at C3 were reduced, both the hydroxylation and lyase reactions proceeded efficiently. Keto Acids cytochrome P450 family 17 subfamily A member 1 Homo sapiens