Pub. Date : 2020
PMID : 32002328
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the transcriptome of aryl hydrocarbon receptor (AhR) knock-down porcine granulosa cells. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor | Homo sapiens |
2 | The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the transcriptome of aryl hydrocarbon receptor (AhR) knock-down porcine granulosa cells. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor | Homo sapiens |
3 | The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the transcriptome of aryl hydrocarbon receptor (AhR) knock-down porcine granulosa cells. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor | Homo sapiens |
4 | The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the transcriptome of aryl hydrocarbon receptor (AhR) knock-down porcine granulosa cells. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor | Homo sapiens |
5 | The well-characterized canonical mechanism of TCDD action involves the activation of aryl hydrocarbon receptor (AhR) pathway, but AhR-independent mechanisms were also suggested. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor | Homo sapiens |
6 | The well-characterized canonical mechanism of TCDD action involves the activation of aryl hydrocarbon receptor (AhR) pathway, but AhR-independent mechanisms were also suggested. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor | Homo sapiens |
7 | The well-characterized canonical mechanism of TCDD action involves the activation of aryl hydrocarbon receptor (AhR) pathway, but AhR-independent mechanisms were also suggested. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor | Homo sapiens |
8 | By applying RNA interference technology and Next Generation Sequencing (NGS) we aimed to identify genes involved in the mechanism of TCDD action in AhR knock-down porcine granulosa cells. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor | Homo sapiens |
9 | After transfection, medium was exchanged and the AhR knock-down cells were treated with TCDD (100 nM) for 3, 12 or 24 h, total cellular RNA was isolated and designated for NGS. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor | Homo sapiens |
10 | In TCDD-treated AhR knock-down cells we identified 360 differentially expressed genes (DEGs; P-adjusted < 0.05 and log2 fold change [log2FC] >= 1.0). | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor | Homo sapiens |
11 | The three-time point study demonstrated that TCDD-induced changes in the transcriptome of AhR knock-down porcine granulosa cells were especially pronounced during the early stages of the treatment (3 h). | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor | Homo sapiens |
12 | Conclusions: TCDD affected the transcriptome of AhR knock-down porcine granulosa cells. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor | Homo sapiens |
13 | The molecules involved in the AhR-independent action of TCDD were indicated in the study. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor | Homo sapiens |