Title : The GTPase KRAS suppresses the p53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells.

Pub. Date : 2020 Mar 6

PMID : 32001619






1 Functional Relationships(s)
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1 Consistent with this, the IKK inhibitor BAY11-7085 and dominant-negative mutant IkappaBalphaM inhibited NFkappaB activity and increased P-P53, P53, and P21/WAF1/CIP1 levels in a ROS-dependent manner. BAY 11-7085 nuclear factor kappa B subunit 1 Homo sapiens