Title : Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation.

Pub. Date : 2020 Jan 30

PMID : 31999252






1 Functional Relationships(s)
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1 The structures define the mechanism of filament assembly, and reveal how filament-dependent allosteric regulation of IMPDH2 makes the enzyme less sensitive to feedback inhibition, explaining why assembly occurs under physiological conditions that require expansion of guanine nucleotide pools. Guanine Nucleotides inosine monophosphate dehydrogenase 2 Homo sapiens