Protein Name inosine monophosphate dehydrogenase 2
Organism Homo sapiens
Gene ID 3615
Gene Symbol

IMPDH2

UniProt P12268 (IMDH2_HUMAN), A0A384N6C2 (A0A384N6C2_HUMAN)
Relationships Total Number of functionally related compound(s) : 58
Total Number of Articles : 70
Description

inosine monophosphate dehydrogenase 2

Gene Summary

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]

synonyms
  • inosine-5'-monophosphate dehydrogenase 2
  • IMP (inosine 5'-monophosphate) dehydrogenase 2
  • IMP (inosine monophosphate) dehydrogenase 2
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Properties