Pub. Date : 2020
PMID : 31998447
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we found that the administration of metformin improved functional recovery after SCI through reducing neuronal cell apoptosis and repairing neurites by stabilizing microtubules via PI3K/Akt signaling pathway. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Inhibiting the PI3K/Akt pathway with LY294002 partly reversed the therapeutic effects of metformin on SCI in vitro and vivo. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Taken together, these results revealed that the role of metformin in nerve regeneration after SCI was probably related to stabilization of microtubules and inhibition of the excessive activation of Akt-mediated Nrf2/ARE pathway-regulated oxidative stress and mitochondrial dysfunction. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |