PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31998447-5	2020	In this study, we found that the administration of metformin improved functional recovery after SCI through reducing neuronal cell apoptosis and repairing neurites by stabilizing microtubules via PI3K/Akt signaling pathway.	Metformin	51-60	AKT serine/threonine kinase 1	Homo sapiens	201-204	
31998447-6	2020	Inhibiting the PI3K/Akt pathway with LY294002 partly reversed the therapeutic effects of metformin on SCI in vitro and vivo.	Metformin	89-98	AKT serine/threonine kinase 1	Homo sapiens	20-23	
31998447-10	2020	Taken together, these results revealed that the role of metformin in nerve regeneration after SCI was probably related to stabilization of microtubules and inhibition of the excessive activation of Akt-mediated Nrf2/ARE pathway-regulated oxidative stress and mitochondrial dysfunction.	Metformin	56-65	AKT serine/threonine kinase 1	Homo sapiens	198-201