Title : Novel complementary antitumour effects of celastrol and metformin by targeting IκBκB, apoptosis and NLRP3 inflammasome activation in diethylnitrosamine-induced murine hepatocarcinogenesis.

Pub. Date : 2020 Feb

PMID : 31989218






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1 In conclusion, by inhibiting NLRP3 inflammasome and its prerequisite NFkappaB signalling, simultaneous administration of metformin and celastrol appears to have additive benefits in the treatment of HCC compared to cela monotherapy. celastrol nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus