Pub. Date : 2020 Apr 6
PMID : 31980815
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we show that the NEIL3 and the FA/BRCA pathways are non-epistatic in psoralen-ICL repair. | psoralen A | nei like DNA glycosylase 3 | Homo sapiens |
| 2 | The NEIL3 pathway is the major pathway for repairing psoralen-ICL, and the FA/BRCA pathway is only activated when NEIL3 is not present. | psoralen A | nei like DNA glycosylase 3 | Homo sapiens |
| 3 | Mechanistically, NEIL3 is recruited to psoralen-ICL in a rapid, PARP-dependent manner. | psoralen A | nei like DNA glycosylase 3 | Homo sapiens |
| 4 | Importantly, the NEIL3 pathway repairs psoralen-ICLs without generating double-strand breaks (DSBs), unlike the FA/BRCA pathway. | psoralen A | nei like DNA glycosylase 3 | Homo sapiens |
| 5 | In addition, we found that the RUVBL1/2 complex physically interact with NEIL3 and function within the NEIL3 pathway in psoralen-ICL repair. | psoralen A | nei like DNA glycosylase 3 | Homo sapiens |
| 6 | In addition, we found that the RUVBL1/2 complex physically interact with NEIL3 and function within the NEIL3 pathway in psoralen-ICL repair. | psoralen A | nei like DNA glycosylase 3 | Homo sapiens |
| 7 | Taken together, the NEIL3 pathway is the major pathway to repair psoralen-ICL through a unique DSB-free mechanism in human cells. | psoralen A | nei like DNA glycosylase 3 | Homo sapiens |