Title : Synthesis and validation of [18F]mBPET-1, a fluorine-18 labelled mTOR inhibitor derivative based on a benzofuran backbone.

Pub. Date : 2020 Jan 23

PMID : 31974638






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1 Synthesis and validation of [18F]mBPET-1, a fluorine-18 labelled mTOR inhibitor derivative based on a benzofuran backbone. benzofuran mechanistic target of rapamycin kinase Homo sapiens
2 Based on the structure of a mTOR inhibitor specific for mTORC1, we designed, synthesised and characterised a novel benzofuran based molecular probe which suits late stage fluorination via Click chemistry. benzofuran mechanistic target of rapamycin kinase Homo sapiens