Title : Vitamin B6 inhibits macrophage activation to prevent lipopolysaccharide-induced acute pneumonia in mice.

Pub. Date : 2020 Mar

PMID : 31970902






1 Functional Relationships(s)
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1 Exposure of cultured primary macrophages to VitB6 increased AMP-activated protein kinase (AMPK) Thr172 phosphorylation in a time/dose-dependent manner, which was inhibited by compound C. VitB6 downregulated the inflammatory gene expressions including IL-1beta, IL-6 and TNF-alpha in macrophages challenged with LPS. Adenosine Monophosphate interleukin 6 Mus musculus