Pub. Date : 2017
PMID : 31966810
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hyperoside inhibited the migration and invasion of lung cancer cells through the upregulation of PI3K/AKT and p38 MAPK pathways. | hyperoside | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | The aim of the present study was to investigate whether low concentrations of Hyp (1-10 muM) could inhibit the invasion and migration of lung cancer cells through regulation of phosphoinositide-3-kinase/serine threonine kinase (PI3K/AKT) and p38 mitogen-activated protein kinase (p38 MAPK) pathways.CCK8 assay was performed to identify the cell viability after human A549 cells treated with Hyp (1, 2 and 5 muM) 12, 24 and 48 h. Hyp (1, 2 and 5 muM) significantly suppressed the invasion and migration of A549 cells in a dose-dependant manner. | hyperoside | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | The aim of the present study was to investigate whether low concentrations of Hyp (1-10 muM) could inhibit the invasion and migration of lung cancer cells through regulation of phosphoinositide-3-kinase/serine threonine kinase (PI3K/AKT) and p38 mitogen-activated protein kinase (p38 MAPK) pathways.CCK8 assay was performed to identify the cell viability after human A549 cells treated with Hyp (1, 2 and 5 muM) 12, 24 and 48 h. Hyp (1, 2 and 5 muM) significantly suppressed the invasion and migration of A549 cells in a dose-dependant manner. | hyperoside | mitogen-activated protein kinase 14 | Homo sapiens |
| 4 | These results suggested that Hyp significantly suppressed the invasion and migration of A549 cells by mediating the AKT/PI3K and p38 MAPK pathways and regulated the expressions of invasion and migration related genes. | hyperoside | mitogen-activated protein kinase 14 | Homo sapiens |