Title : α-Lipoic acid prevents the ionizing radiation-induced epithelial-mesenchymal transition and enhances the radiosensitivity in breast cancer cells.

Pub. Date : 2020 Mar 15

PMID : 31958458






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Lipoic acid also prevented the TGFbeta1 release and inhibited the radiation-induced EMT in breast cancer cells. Thioctic Acid transforming growth factor beta 1 Homo sapiens
2 The inhibition of TGFbeta signaling by lipoic acid is associated with the inhibition of radiation-induced activation and translocation of NF-kappaB. Thioctic Acid transforming growth factor beta 1 Homo sapiens
3 These results suggest that alpha-lipoic acid inhibits the radiation-induced TGFbeta signaling and nuclear translocation of NF-kappaB, thereby inhibiting the radiation-induced EMT and sensitizing the breast cancer cells to ionizing radiation. Thioctic Acid transforming growth factor beta 1 Homo sapiens