Pub. Date : 2020 Mar 1
PMID : 31953353
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, to our knowledge, we uncover that ORP5L interacts physically with PLCgamma1 in T cells, extracts PIP2 from the plasma membrane via its ORD domain (OSBP-related domain), presents it to PLCgamma1 (enabling IP3 generation), and eventually maintains intracellular Ca2+ homeostasis. | Phosphatidylinositol 4,5-Diphosphate | phospholipase C gamma 1 | Homo sapiens |
| 2 | In this study, to our knowledge, we uncover that ORP5L interacts physically with PLCgamma1 in T cells, extracts PIP2 from the plasma membrane via its ORD domain (OSBP-related domain), presents it to PLCgamma1 (enabling IP3 generation), and eventually maintains intracellular Ca2+ homeostasis. | Phosphatidylinositol 4,5-Diphosphate | phospholipase C gamma 1 | Homo sapiens |