Title : In vitro exposure to metformin activates human spermatozoa at therapeutically relevant concentrations.

Pub. Date : 2020 May

PMID : 31944615






4 Functional Relationships(s)
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1 In addition, activation of AMPK by A769662 (an AMPK activator) had similar effects to metformin on human spermatozoa, while inhibition of AMPK by compound C (an AMPK inhibitor) suppressed the enhancement of metformin on human spermatozoa. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
2 In addition, activation of AMPK by A769662 (an AMPK activator) had similar effects to metformin on human spermatozoa, while inhibition of AMPK by compound C (an AMPK inhibitor) suppressed the enhancement of metformin on human spermatozoa. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
3 In addition, activation of AMPK by A769662 (an AMPK activator) had similar effects to metformin on human spermatozoa, while inhibition of AMPK by compound C (an AMPK inhibitor) suppressed the enhancement of metformin on human spermatozoa. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
4 In addition, activation of AMPK by A769662 (an AMPK activator) had similar effects to metformin on human spermatozoa, while inhibition of AMPK by compound C (an AMPK inhibitor) suppressed the enhancement of metformin on human spermatozoa. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens