Title : The Shc protein Rai enhances T-cell survival under hypoxia.

Pub. Date : 2020 Nov

PMID : 31944299






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Upon exposure to hypoxia, Jurkat T cells expressing Rai show (a) higher HIF-1alpha protein levels; (b) a decreased cell death and increased Akt/extracellular-signal-regulated kinase phosphorylation; (c) a decreased expression of proapoptotic markers, including caspase activities and poly(ADP-ribose) polymerase cleavage; (d) an increased glucose and lactate metabolism; (e) an increased activation of nuclear factor-kB pathway. Glucose hypoxia inducible factor 1 subunit alpha Homo sapiens