Title : Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C19-steroids.

Pub. Date : 2020 May

PMID : 31926269






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 2) Val200 is a critical determinant for exhibiting the strict 17beta-HSD activity of the enzyme, because the Val200Leu mutation resulted in both significant impairment of the 17beta-HSD activity and emergence of 3beta-HSD activity towards 5alpha-androstanes including 11KDHT. androstane hydroxysteroid 17-beta dehydrogenase 1 Homo sapiens
2 2) Val200 is a critical determinant for exhibiting the strict 17beta-HSD activity of the enzyme, because the Val200Leu mutation resulted in both significant impairment of the 17beta-HSD activity and emergence of 3beta-HSD activity towards 5alpha-androstanes including 11KDHT. androstane hydroxysteroid 17-beta dehydrogenase 1 Homo sapiens