Title : Inhibition of kras-derived exosomes downregulates immunosuppressive BACH2/GATA-3 expression via RIP-3 dependent necroptosis and miR-146/miR-210 modulation.

Pub. Date : 2020 Feb

PMID : 31918262






1 Functional Relationships(s)
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1 Furthermore, exosomal Kras inhibition downregulated transcription factor BACH2/GATA-3 expression in lung tumor tissues by shifting pyruvate/PKM2 dependent metabolism, contributing to a tumor-restraining status. Pyruvates KRAS proto-oncogene, GTPase Homo sapiens