Pub. Date : 2020 Apr
PMID : 31917285
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Icariside II attenuates eosinophils-induced airway inflammation and remodeling via inactivation of NF-kappaB and STAT3 in an asthma mouse model. | baohuoside I | signal transducer and activator of transcription 3 | Mus musculus |
| 2 | In both OVA-induced mouse model of asthma and TGF-beta1-induced ASMCs, Icariside II decreased IkappaBalpha degradation, nuclear translocation of NF-kappaB p65 and STAT3 phophorylation, indicating an inactivation of NF-kappaB and STAT3 in the presence of Icariside II. | baohuoside I | signal transducer and activator of transcription 3 | Mus musculus |
| 3 | In both OVA-induced mouse model of asthma and TGF-beta1-induced ASMCs, Icariside II decreased IkappaBalpha degradation, nuclear translocation of NF-kappaB p65 and STAT3 phophorylation, indicating an inactivation of NF-kappaB and STAT3 in the presence of Icariside II. | baohuoside I | signal transducer and activator of transcription 3 | Mus musculus |
| 4 | Therefore, we demonstrate that Icariside II attenuates eosinophils-induced airway inflammation and remodeling in asthmatic mice and inhibits TGF-beta1-induced cell proliferation and migration in ASMCs via suppressing NF-kappaB and STAT3 signalings. | baohuoside I | signal transducer and activator of transcription 3 | Mus musculus |