Pub. Date : 2019
PMID : 31911861
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Moreover, we found that the alpha5/FAK/PI3K/AKT signal axis is activated in Res cells, which mediates the increased expression of BARD1, as well as the cisplatin resistance and cell survival. | Cisplatin | protein tyrosine kinase 2 | Homo sapiens |
| 2 | Thus, our results demonstrate that alpha5 is required for cisplatin resistance through the promotion of FAK/PI3K/AKT/BARD1 signaling to prevent cells from apoptosis and enhance the DNA damage repair ability. | Cisplatin | protein tyrosine kinase 2 | Homo sapiens |