Title : Activation of α7 nAChR by PNU-282987 improves synaptic and cognitive functions through restoring the expression of synaptic-associated proteins and the CaM-CaMKII-CREB signaling pathway.

Pub. Date : 2020 Jan 6

PMID : 31905173






1 Functional Relationships(s)
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1 Collectively, the activation of alpha7 nAChR by PNU-282987 attenuated the toxic effect of Abeta in vivo and in vitro, which including reduced deposition of Abeta in the hippocampus, maintained synaptic morphology by partially reversing the expression levels of synaptic-associated proteins, activation of the Ca2+ signaling pathway, and improvement of the cognitive abilities of APP/PS1_DT mice. PNU-282987 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus