Pub. Date : 2020 May 1
PMID : 31904416
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The silencing of AMPK-increased cellular cholesterol and stabilized lysosomes against Dp44mT-mediated lysosomal membrane permeabilization. | Cholesterol | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | This was substantiated by studies demonstrating that the cholesterol-depleting agent, methyl-beta-cyclodextrin (MbetaCD), restores Dp44mT-mediated lysosomal membrane permeabilization in AMPK silenced cells. | Cholesterol | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | The increased levels of cholesterol after AMPK silencing were independent of the ability of AMPK to inhibit the rate-limiting step of cholesterol synthesis via the inactivating phosphorylation of 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR) at Ser872. | Cholesterol | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |