Title : Modeling Neoadjuvant chemotherapy resistance in vitro increased NRP-1 and HER2 expression and converted MCF7 breast cancer subtype.

Pub. Date : 2020 May

PMID : 31883395






1 Functional Relationships(s)
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1 In turn, resistant MCF7 cells to Adriamycin/cyclophosphamide (4xAC), induced HER2 expression which converted MCF7 subtype from being a luminal A to luminal B-HER2 type, upregulated NRP-1, ER-alpha, and EGFR and activated PI3K/AKT/NF-kappaBp65 axis. Doxorubicin epidermal growth factor receptor Homo sapiens