Title : Discovery of 5-(pyridin-3-yl)-1H-indole-4,7-diones as indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.

Pub. Date : 2020 Feb 15

PMID : 31882299






1 Functional Relationships(s)
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1 Herein, in order to simplify the structure of two kinds of IDO1 inhibitors from marine alkaloid, Exiguamine A and Tsitsikammamines, we designed, synthesized a series of 1H-indole-4,7-dione derivatives and evaluated their inhibitory activity in IDO1 enzyme and in IFN-gamma stimulated Hela cells in vitro. Isatin indoleamine 2,3-dioxygenase 1 Homo sapiens