Pub. Date : 2019 Dec 19
PMID : 31861550
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Unification of Opposites between Two Antioxidant Transcription Factors Nrf1 and Nrf2 in Mediating Distinct Cellular Responses to the Endoplasmic Reticulum Stressor Tunicamycin. | Tunicamycin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | Herein, we report a unity of opposites between these two antioxidant transcription factors, Nrf1 and Nrf2, in coordinating distinct cellular responses to the ER stressor tunicamycin (TU). | Tunicamycin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | Herein, we report a unity of opposites between these two antioxidant transcription factors, Nrf1 and Nrf2, in coordinating distinct cellular responses to the ER stressor tunicamycin (TU). | Tunicamycin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | The TU-inducible transcription of Nrf1 and Nrf2, as well as GCLM (glutamate cysteine ligase modifier subunit) and HO-1 (heme oxygenase 1), was accompanied by activation of ER stress signaling networks. | Tunicamycin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 5 | Thus, it is inferred that such distinct roles of Nrf1 and Nrf2 are unified to maintain cell homeostasis by a series of coordinated ER-to-nuclear signaling responses to TU. | Tunicamycin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 6 | Interestingly, Nrf1 is more potent than Nrf2 at mediating the cytoprotective responses against the cytotoxicity of TU alone plus tBHQ (tert-butylhydroquinone). | Tunicamycin | NFE2 like bZIP transcription factor 2 | Homo sapiens |