Title : EGFR Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma.

Pub. Date : 2020 Mar 15

PMID : 31852834






2 Functional Relationships(s)
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Protein Name
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1 EGFR amplification was associated with increased reactive oxygen species (ROS) and subsequent increased basal expression of DNA-repair pathways to counterelevated oxidative stress, and thus rendered vulnerability to PARP inhibition. Reactive Oxygen Species epidermal growth factor receptor Homo sapiens
2 EGFR amplification was associated with increased reactive oxygen species (ROS) and subsequent increased basal expression of DNA-repair pathways to counterelevated oxidative stress, and thus rendered vulnerability to PARP inhibition. Reactive Oxygen Species epidermal growth factor receptor Homo sapiens