Title : The small fiber neuropathy NaV1.7 I228M mutation: impaired neurite integrity via bioenergetic and mitotoxic mechanisms, and protection by dexpramipexole.

Pub. Date : 2020 Feb 1

PMID : 31851560






3 Functional Relationships(s)
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1 Using an ATP FRET biosensor, we now demonstrate reduced steady-state levels of ATP and markedly faster ATP decay in response to membrane depolarization in cultured DRG neurons expressing an SFN-associated variant NaV1.7, I228M, compared to WT neurons. Adenosine Triphosphate RNA exonuclease 2 Homo sapiens
2 Using an ATP FRET biosensor, we now demonstrate reduced steady-state levels of ATP and markedly faster ATP decay in response to membrane depolarization in cultured DRG neurons expressing an SFN-associated variant NaV1.7, I228M, compared to WT neurons. Adenosine Triphosphate RNA exonuclease 2 Homo sapiens
3 Using an ATP FRET biosensor, we now demonstrate reduced steady-state levels of ATP and markedly faster ATP decay in response to membrane depolarization in cultured DRG neurons expressing an SFN-associated variant NaV1.7, I228M, compared to WT neurons. Adenosine Triphosphate RNA exonuclease 2 Homo sapiens