Pub. Date : 2020
PMID : 31839606
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we have found that GMP-1 specifically binds to copper and zinc, metals that are dysregulated in AD brain. | Copper | small ubiquitin like modifier 1 | Homo sapiens |
| 2 | Also, binding of Zn(II) and Cu(II) by GMP-1 is weaker than the 8-hydroxyquinoline scaffold compound clioquinol previously tested in AD clinical trials. | Copper | small ubiquitin like modifier 1 | Homo sapiens |
| 3 | However, GMP-1 affects Cu(II)-dependent Abeta fibrillization as well as oxidative damage and viability of SH-SY5Y cells upon addition of Cu(II) and Abeta. | Copper | small ubiquitin like modifier 1 | Homo sapiens |
| 4 | Our data provide new insight on GMP-1 as a Zn(II) and Cu(II) specific metal chelator of moderate affinity that can be responsible for some of its neuroprotective effects observed in AD animal models. | Copper | small ubiquitin like modifier 1 | Homo sapiens |