Pub. Date : 2019 Dec 14
PMID : 31837261
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study aimed to investigate the effect of orientin on proliferation and apoptosis of T24 human transitional cell bladder carcinoma cells in vitro in the presence of an agonist and an inhibitor of nuclear factor-kappaB (NF-kappaB). | orientin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | MATERIAL AND METHODS T24 cells were cultured and divided into four study groups: an untreated control group; a group treated with 100 muM orientin; a group treated with 100 muM orientin with NF-kappaB agonist, phorbol 12-myristate 13-acetate (PMA); and a group treated with 100 muM orientin and the NF-kappaB inhibitor, IkappaBalpha. | orientin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | MATERIAL AND METHODS T24 cells were cultured and divided into four study groups: an untreated control group; a group treated with 100 muM orientin; a group treated with 100 muM orientin with NF-kappaB agonist, phorbol 12-myristate 13-acetate (PMA); and a group treated with 100 muM orientin and the NF-kappaB inhibitor, IkappaBalpha. | orientin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | MATERIAL AND METHODS T24 cells were cultured and divided into four study groups: an untreated control group; a group treated with 100 muM orientin; a group treated with 100 muM orientin with NF-kappaB agonist, phorbol 12-myristate 13-acetate (PMA); and a group treated with 100 muM orientin and the NF-kappaB inhibitor, IkappaBalpha. | orientin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | MATERIAL AND METHODS T24 cells were cultured and divided into four study groups: an untreated control group; a group treated with 100 muM orientin; a group treated with 100 muM orientin with NF-kappaB agonist, phorbol 12-myristate 13-acetate (PMA); and a group treated with 100 muM orientin and the NF-kappaB inhibitor, IkappaBalpha. | orientin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 6 | Treatment of T24 cells with orientin inhibited the expression of NF-kappaB and components of the Hedgehog signaling pathway, and the NF-kappaB agonist, PMA, reversed these effects. | orientin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 7 | CONCLUSIONS Treatment of T24 human bladder carcinoma cells in vitro with orientin inhibited cell proliferation and promoted cell apoptosis by suppressing the Hedgehog signaling pathway and NF-kappaB. | orientin | nuclear factor kappa B subunit 1 | Homo sapiens |