Title : Expression of XBP1s in peritoneal mesothelial cells is critical for inflammation-induced peritoneal fibrosis.

Pub. Date : 2019 Dec 13

PMID : 31836774






1 Functional Relationships(s)
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1 However, these effects were prevented by the IRE1 endonuclease inhibitor STF083010 since it time-dependently reduced IL-1beta-induced Xbp1 mRNA splicing, XBP1s protein expression, inflammatory factor IL-6 secretion and the expression of the fibrotic marker fibronectin in human peritoneal mesothelial cells (HPMCs). STF 083010 X-box binding protein 1 Homo sapiens