Title : NLRP3 inhibitor glibenclamide attenuates high-fat diet and streptozotocin-induced non-alcoholic fatty liver disease in rat: studies on oxidative stress, inflammation, DNA damage and insulin signalling pathway.

Pub. Date : 2020 Apr

PMID : 31834465






4 Functional Relationships(s)
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1 NLRP3 inhibitor glibenclamide attenuates high-fat diet and streptozotocin-induced non-alcoholic fatty liver disease in rat: studies on oxidative stress, inflammation, DNA damage and insulin signalling pathway. Glyburide NLR family, pyrin domain containing 3 Rattus norvegicus
2 Glibenclamide (GLB) is a potent NLRP3 inflammasome inhibitor and possesses anti-inflammatory and anti-oxidant properties. Glyburide NLR family, pyrin domain containing 3 Rattus norvegicus
3 Glibenclamide (GLB) is a potent NLRP3 inflammasome inhibitor and possesses anti-inflammatory and anti-oxidant properties. Glyburide NLR family, pyrin domain containing 3 Rattus norvegicus
4 Immunohistochemical and immunoblotting findings showed that GLB improved the hepatic expressions of inflammatory markers (NLRP3, ASC, caspase-1, IL-1beta, NF-kappaB), anti-oxidant markers (SOD, catalase) and insulin signalling markers (p-AKT, p-GSK-3beta, p-IRS). Glyburide NLR family, pyrin domain containing 3 Rattus norvegicus