Title : Diosmetin exhibits anti-proliferative and anti-inflammatory effects on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes through regulating the Akt and NF-κB signaling pathways.

Pub. Date : 2020 Jun

PMID : 31833613






4 Functional Relationships(s)
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Protein Name
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1 Diosmetin exhibits anti-proliferative and anti-inflammatory effects on TNF-alpha-stimulated human rheumatoid arthritis fibroblast-like synoviocytes through regulating the Akt and NF-kappaB signaling pathways. diosmetin AKT serine/threonine kinase 1 Homo sapiens
2 Furthermore, diosmetin inhibited TNF-alpha-induced activation of protein kinase B (Akt) and nuclear factor-kappaB (NF-kappaB) pathways in MH7A cells. diosmetin AKT serine/threonine kinase 1 Homo sapiens
3 Suppression of Akt or NF-kappaB promoted apoptosis and inhibited TNF-alpha-induced proliferation increase and production of IL-1beta, IL-6, IL-8, and MMP-1 in MH7A cells, and diosmetin treatment enhanced these effects. diosmetin AKT serine/threonine kinase 1 Homo sapiens
4 Taken together, these findings suggested that diosmetin exhibited anti-proliferative and anti-inflammatory effects via inhibiting the Akt and NF-kappaB pathways in MH7A cells. diosmetin AKT serine/threonine kinase 1 Homo sapiens