PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31833613-0 2020 Diosmetin exhibits anti-proliferative and anti-inflammatory effects on TNF-alpha-stimulated human rheumatoid arthritis fibroblast-like synoviocytes through regulating the Akt and NF-kappaB signaling pathways. diosmetin 0-9 AKT serine/threonine kinase 1 Homo sapiens 171-174 31833613-9 2020 Furthermore, diosmetin inhibited TNF-alpha-induced activation of protein kinase B (Akt) and nuclear factor-kappaB (NF-kappaB) pathways in MH7A cells. diosmetin 13-22 AKT serine/threonine kinase 1 Homo sapiens 83-86 31833613-10 2020 Suppression of Akt or NF-kappaB promoted apoptosis and inhibited TNF-alpha-induced proliferation increase and production of IL-1beta, IL-6, IL-8, and MMP-1 in MH7A cells, and diosmetin treatment enhanced these effects. diosmetin 175-184 AKT serine/threonine kinase 1 Homo sapiens 15-18 31833613-11 2020 Taken together, these findings suggested that diosmetin exhibited anti-proliferative and anti-inflammatory effects via inhibiting the Akt and NF-kappaB pathways in MH7A cells. diosmetin 46-55 AKT serine/threonine kinase 1 Homo sapiens 134-137