Pub. Date : 2019 Dec 13
PMID : 31828178
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lack of CYP7B1 leads to an accumulation of its oxysterol substrates, in particular 25-hydroxycholesterol and 27-hydroxycholesterol that are able to cross the blood-brain barrier and have neurotoxic properties. | arthrofactin | cytochrome P450 family 7 subfamily B member 1 | Homo sapiens |
| 2 | A single-dose injection of either mouse or human CYP7B1 mRNA led to a pronounced degradation of oxysterols in liver and serum within 2 days of treatment. | arthrofactin | cytochrome P450 family 7 subfamily B member 1 | Homo sapiens |
| 3 | Pharmacokinetics indicate a single injection of human CYP7B1 mRNA to be effective in reducing oxysterols for at least 5 days. | arthrofactin | cytochrome P450 family 7 subfamily B member 1 | Homo sapiens |