Pub. Date : 2021
PMID : 31820701
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Network Pharmacology Approach uncovering Pathways involved in targeting Hsp90 through Curcumin and Epigallocatechin to control Inflammation. | Curcumin | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 2 | Curcumin and EGC were also found to bind -N and -C terminal domain of Hsp90 respectively. | Curcumin | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 3 | Hsp90 associated gene targets of Curcumin and EGC were collected from databases, and gene ontology studies were done. | Curcumin | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 4 | Main proteins involved were identified as key regulators in Pkcdelta-Nrf2 and Tlr4 pathway for controlling expression of Hsp90 from Curcumin and EGC in inflammation. | Curcumin | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 5 | Docking was performed on main proteins, Hsp90, Pkcdelta and Tlr4 with Curcumin and EGC, significant binding energy was obtained for docked complexes. | Curcumin | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 6 | Present study is an attempt to unravel common pathways mediated in intervention of Curcumin and EGC for suppression of Hsp90 associated with inflammation. | Curcumin | heat shock protein 90 alpha family class A member 1 | Homo sapiens |