PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31820701-0 2021 Network Pharmacology Approach uncovering Pathways involved in targeting Hsp90 through Curcumin and Epigallocatechin to control Inflammation. Curcumin 86-94 heat shock protein 90 alpha family class A member 1 Homo sapiens 72-77 31820701-4 2021 Curcumin and EGC were also found to bind -N and -C terminal domain of Hsp90 respectively. Curcumin 0-8 heat shock protein 90 alpha family class A member 1 Homo sapiens 70-75 31820701-6 2021 Hsp90 associated gene targets of Curcumin and EGC were collected from databases, and gene ontology studies were done. Curcumin 33-41 heat shock protein 90 alpha family class A member 1 Homo sapiens 0-5 31820701-10 2021 Main proteins involved were identified as key regulators in Pkcdelta-Nrf2 and Tlr4 pathway for controlling expression of Hsp90 from Curcumin and EGC in inflammation. Curcumin 132-140 heat shock protein 90 alpha family class A member 1 Homo sapiens 121-126 31820701-11 2021 Docking was performed on main proteins, Hsp90, Pkcdelta and Tlr4 with Curcumin and EGC, significant binding energy was obtained for docked complexes. Curcumin 70-78 heat shock protein 90 alpha family class A member 1 Homo sapiens 40-45 31820701-13 2021 Present study is an attempt to unravel common pathways mediated in intervention of Curcumin and EGC for suppression of Hsp90 associated with inflammation. Curcumin 83-91 heat shock protein 90 alpha family class A member 1 Homo sapiens 119-124